Biochemical basis of ΔFosB's unique stability: (a) FosB (338 aa, Mr approx. 38 kD) and (b) ΔFosB (237 aa, Mr approx. 26 kD) are encoded by the fosB gene. ΔFosB is generated by alternative splicing and lacks the C-terminal 101 amino acids present in FosB. Two mechanisms are known that account for ΔFosB's stability. First, ΔFosB lacks two degron domains present in the C-terminus of full-length FosB (and found in all other Fos family proteins as well). One of these degron domains targets FosB for ubiquitination and degradation in the proteasome. The other degron domain targets FosB degradation by a ubiquitin- and proteasome-independent mechanism. Second, ΔFosB is phosphorylated by casein kinase 2 (CK2) and probably by other protein kinases (?) at its N-terminus, which further stabilizes the protein.

This was created based on Transcriptional mechanisms of addiction: role of ΔFosB, by Eric J Nestler, PMCID: PMC2607320 PMID: 18640924. However, the image was not auto-traced from either source image. The relative similarity was reproduced as accurately as possible from Figure 1 (https://pmc.ncbi.nlm.nih.gov/articles/PMC2607320/figure/fig1/) as a guide when this image was drawn. Minor differences to the wording of some labels were also introduced in this file relative to the original, and a translation to catalan too. The description above is from the original paper too

Per section 921 on the copyrightability of graphs, charts, tables, and figures from this publication by the US government Copyright Office, I'm not entirely sure these images are actually copyrightable; however, the aforementioned variations in this image relative to the original were introduced in the event that the the text and limited compilation of lines/curves within the images actually satisfy the minimum requiements for copyrightability. In other words, I (User:BQUB24-Ddominguez) hold the copyright to this version of the image, assuming it's actually copyrightable. I would prefer that the source images be linked or reused (in compliance with their copyright licensing terms) in place of this file whenever feasible or possible though since the depicted temporal variations in gene expression upon initial and repeated drug exposure are findings from Dr. Nestler's original research.

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